CHEM 2443 Chapter Notes - Chapter 8: Joule, Cyclohexane Conformation, Hp 48 Series
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Chair cyclohexane with one substituent: if one of the axial hydrogen atoms is replaced with the larger chlorine atom, the steric interaction is much greater. This type of steric strain is generically called transannular strain, so a 1,3 strain is one type of transannular strain: this type of steric effect only occurs in chair cyclohexane (a1,3 strain) and derivatives of chair cyclohexane. A 1,3 strain in chair cyclohexane: monosubstituted cyclohexane 56 has an equilibrating chair conformation 57. In 56, the r group is axial and there is a the 2 axial hydrogen atoms. 1,3 strain due to the interaction of the r group with. 1,3 strain (or just a-strain) in a monosubstituted cyclohexane is due to the interaction of the r group with the axial hydrogens on that side" of the molecule. See 48f: in 57, the r group is equatorial, and there is no a.
