DGS 3223 Chapter Notes - Chapter 3: Globulin, Aflatoxin, Cytogenetics
8 Sep 2016
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The mutated triplet codes for a different amino acid. The final protein product differs by one amino acid. A t is substituted for an a in one of the 146 amino acids in the beta globulin molecule. Results in an incomplete protein product (a truncated protein: frameshift mutations. Insertions or deletions of one or more nucleotides into the dna molecule. Protein synthesis continues until a stop-codon is produced. A common mutation results from a 3-base-pair deletion: dynamic mutations. Abnormal expansion of trinucleotide repeats within an individual gene. 200 or more repeats of cgg on the x chromosome. 42-100 repeats of cag on chromosome 4. Avery welch medical cytogenetics prelim 1 chapter 3 chromosomal mutations. Chromosomal aberrations: gross changes in chromosomal structure, all types of mutations we talk about happen in low frequency but certain environmental factors speed it up. Classes of chemical mutagens: base pair mutagens. Chemicals that alter the structure of a base causing mis-pairing.
