MCB 3211 Chapter 7: Chapter 7 Cancer Cells Notes
7 Mar 2017
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Tumor suppressor genes are recessive- both copies of a tumor suppressor gene need to be mutated in order for transformation to occut; oncogenes are domiant. Tumor suppressor genes- decrease mutations and promote cellular repair. Familial retinoblastoma- one mutated rb allele already exists. Rb is a gatekeeper tumor suppressor gene. Rb on chromosome 13; next to esteraes d. Methylation can occur on cpgs- methylation of tumor suppressor genes makes their function silent, effectivly deleting them. Cpgs area not distrubuted evenly throught the genome, often they occur at promoters and are unmethylated, the opposite occurs in cancers. Dnamt1 and 3 methylate stuff- commonly mutated in many cancers -overexpressed. Brca 1 gene is silenced in many tumors; in familial breast cancer it is lost throught mutation. Nf -/- is responsible for familia neurofibromatosis. Rates of fap and hnpcc greatly increase with age. Vhl-( tumor syndrome when mutated ) regulates hif-1 and suppresses vegf.
