BIPN 102 Chapter Notes - Chapter 16: Globular Protein, Magnetic Core, Membrane Transport Protein
1 Apr 2019
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Red blood cells: most abundant cell type in blood, function: facilitates oxygen transport from lungs to cells and co2 transport from cells to lungs, hematocrit: ratio of rbcs to plasma. Expressed as % total blood volume: 40-54% for men, 35-47% for women, mature rbcs lack a nucleus. In bone marrow, cells differentiate into large, nucleated erythroblasts. As it matures, nucleus condenses and cell shrinks. In last stage before maturation, nucleus pinched off and phagocytized by bone marrow macrophages. Final immature cell form (reticulocyte) leaves marrow -> circulation, for maturation into erythrocyte in. 24 hours: shape of mature rbcs: biconcave disks, membrane held by complex cytoskeleton composed of filaments linked to transmembrane attachment proteins. Still very flexible, so can change shape to move through narrow capillaries and respond to osmotic changes: filled with enzymes and hemoglobin. Don"t have mitochondria, so cannot do aerobic metabolism.
