BIPN 102 Chapter Notes - Chapter 20: Lactic Acidosis, Respiratory Alkalosis, Respiratory Acidosis

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In some cells, very fast from presence of lots of carbonic anhydrase, which catalyzes reaction: homeostatic mechanisms normally prevent co2 from accumulating in the body, base input, diet and metabolism have few significant sources of bases. Some foods contain anions that metabolize to hco3. Leaves rbc in exchange for plasma cl-, the chloride shift: extracellular buffers: plasma bicarbonate produced from metabolic co2, plasma [hco3. ] is 6x105 times as concentrated as plasma h+ (low h+ from hb buffering). Can buffer h+ from nonrespiratory sources, like metabolism. Hco3 in plasma: co2 + h2o -> h2co3 -> h+ + hco3. Acts as buffer and combines with added h+ until equilibrium reached. Therefore, h+ still elevated, but not as much as it was initially. H2o, increasing both: at equilibrium, equation is: Decreased from buffering, and buffered h+ converted to co2 and. Can"t act as a buffer since it doesn"t: change in hco3.

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