BIMM 120 Chapter Notes - Chapter 3: Horizontal Gene Transfer, Genetic Drift, Methicillin

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Learning outcomes of week 1: microbial evolution, how bacteria grow in a lab, horizontal gene transfer and the griffith experiment, phylogenetic trees, and relatedness. Microbial evolution: change of allele frequencies over time: positive selection: process by which new, advantageous mutations spread in a population (sweep) and are therefore able to improve fitness. Genes are involved: genetic drift: effect of chance on populations, genes are not involved. Includes bottleneck and founder effects: bottleneck: disaster in environment causes lack of genetic diversity amongst a population. Population that is left reproduces with genetic material that remains: founders effect: small fraction of a population inhabits a new environment. Small fraction then multiplies, limiting the original genetic diversity: 2 in-class examples of microbial evolution, mrsa: methicillin resistant staphylococcus aureus, antibiotics provided as positive selection: only the bacteria that had survived the antibiotics were able to propagate.

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