SOCI 136F Chapter Notes - Chapter 5: Randomized Controlled Trial, Neurosyphilis, Arsphenamine
Document Summary
Braslow, neurosyphilis, malaria, and a new therapeutic rationale . Malaria therapy used 1920"s to 1940"s to treat general paralysis of the insane (gpi) Introduction of malaria therapy led to dramatic change in physician-patient relationship. Gpi- tertiary form of syphilis that arises 10-20 years after initial infection. Known to have a biological basis, and so gpi was considered a key to future knowledge of the brain (hoped that other disorders would show a biological cause too) Came to symbolize beliefs about somatically based model of mental disorders: affected 20% of male patients in new york, and up to 45% in europe; did not affect women as much. 1909- paul ehrlich developed salvarsan as a treatment (injected into brain and spine), but was not very effective against progression of gpi. Once injected, patients got a fever after 1 week which rose to 106 degrees and lasted several hours before subsiding. A fever-chill cycle lasted for a few days.
