PSYCH 250 Chapter Notes - Chapter 4.23: Creb1, Sensory Neuron, Motor Neuron
Document Summary
Increase in glutamate vessicles that are released in the sensory neuron"s synapse on the motor neuron; similar to senstization: mechanism is similar to sensitization, enhancement of glutamate release brought on by touch and tail shock is: Activity dependent enhancement: activity- dependent enhancement: paired training of the cs and us that produces an increase in the glutamate vesicles released from sensory neurons to motor neurons, kendall and coll. For long term structural changes: two proteins that play roles in creation of synapses, creb-1, activates genes in the neuron"s nucleus that initiate the growth of new synapses. If inactive, fail to show long-lasting forms of associative learning. Inactivity does not affect short-lasting forms of learning: creb-2, plays an opponent role inhibiting the actions of creb-1, when inactivated long lasting learning occurs rapidly; even after single exposure to serotonin. Growth/deletion of synapses are characteristic of long lasting forms of memory.
