PHR 338 Chapter Notes - Chapter 62: Pharmacogenomics, Histamine H2 Receptor, Cytochrome P450
Pharmacology: Inverse Agonists, H2RAs, PPIs and Antacids; CYP450 Drug Metabolism; and
Pharmacogenomics: PPIs – Applications – KEY
24 October 2016, IP2
Class Objectives
At the end of this class (after class), you should be able to:
1. Identify the pathophysiology of gastrointestinal diseases that is targeted by gastrointestinal drugs.
2. Categorize gastrointestinal drugs by class.
3. Categorize gastrointestinal drugs by mechanism of action (MOA).
4. Evaluate the effects of H2 receptor antagonists versus proton pump inhibitors.
5. Explain the mechanism for the CYP450-mediated pharmacogenomic response of PPIs.
Katzung Fig. 62-1
Document Summary
Pharmacology: inverse agonists, h2ras, ppis and antacids; cyp450 drug metabolism; and. Identify the pathophysiology of gastrointestinal diseases that is targeted by gastrointestinal drugs. At the end of this class (after class) , you should be able to: 1: categorize gastrointestinal drugs by class, categorize gastrointestinal drugs by mechanism of action (moa), evaluate the effects of h2 receptor antagonists versus proton pump inhibitors, explain the mechanism for the cyp450-mediated pharmacogenomic response of ppis. Then, what happens with chronic use: antacids: Summarize the reaction and chronic reaction: the acids are weak bases that turn hcl into salt and water. Then, with chronic use lack of luminal stimulation of d cells lack of stimulation of somatostatin release lack of inhibition/regulation of gastrin release: 1) more. Summarize the reaction and chronic reaction: the drug circulates to the h2rs on parietal cells, but does not activate them, and blocks histamine from the ecl cells from binding decreased stimulation of proton pump reduced acid production.
