BIOL 3315 Chapter 9: Genetics Ch. 9 notes
Document Summary
Overview of amino acids & protein structure (5") amino/n-terminus (aa1) (aa2) (aa3) carboxyl/ c-terminus (3") (peptide bond: r = reactive or residue group, peptide group is rigid and planar. Translation - the process that builds the primary structure of a protein using the information encoded in mrna. Protein structure: primary, secondary determined by hydrogen bonds, electrostatic forces, & van der waals forces between amino acids, alpha helix, pleated sheet, tertiary folding of secondary structures, quaternary interactions between different tertiary structures (hemoglobin) The primary structure of a protein will go through its own environment, salt, ph etc. and form into a tertiary structure where we find active sites. Protein structure prediction is a difficult bioinformatics problem. Overview of translation: ribosomes are where things occur. Ribosomal structure a complex of protein and rna. S = svedberg unit describes sedimentation during centrifugation. Peptidyl (p) site = trna with growing polypeptide. Aminoacyl (a) site = trna with next amino acid.
