NSC-2201 Chapter Notes - Chapter 25: Bcm Theory, Second Messenger System, Creb1
1 May 2017
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Memory acquisition: consider learning and memory in two stages, 1. Acquisition of a short term memory: 2. Cellular reports of memory formation: all neurons partake in information storage. It neurons show selectivity: fire most at some familiar faces, firing can increase in speed as faces become more familiar. Invertebrates are preferred because they have fewer neurons that are grouped into specific ganglia and the ganglia are in the same location in each individual: nerve cells form the same reproducible circuits in every animal. Strengthening synapses: long-term potentiation (ltp) discovered in hippocampus. Ca3 branch leaves via fornix > other branch, schaffer collateral, synapses on ca1: circuit above is called trisynaptic circuit because three sets of synapstic connections are involved. Synapses must be stimulated at frequencies high enough to cause temporal summation of epsps: 2. Ampa receptors by phosphorylation by protein kinases > insertion of more. Ap in axon will trigger presynaptic glutamate release.
