BIOL121 Lecture Notes - Lecture 21: Collagen, Heparin, Fibrinolysis
17 Sep 2018
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Transport: oxygen, nutrients, waste, hormones, drugs. Regulation: body temperature, ph, fluid volume. Plasma: makes up 50-60% of blood volume, water and proteins, more than 90% of plasma is water, carries nutrients, hormones, gases, wastes, electrolytes. Cells: 45% of blood, rbc, whc, platelets, all formed in bone marrow (stem cell) Globulins (35%: antibodies (immunoglobulins, transport globulins (small molecules) Fibrinogen (4%: molecules that form clots and produce insoluble strands of fibrin, erythrocytes (red blood cells) Lack nuclei, mitochondria and ribosomes: no repair, anaerobic metabolism, live about 120 days. Complex quaternary structure: each subunit with one molecule of haeme, each haeme molecule contains one iron (fe2+) ion. Iron (fe2+) ions: associate easily with o2 (oxyhaemoglobin, hbo2, dissociate easily from o2 (deoxyhemoglobin) With low oxygen (peripheral capillaries: haemoglobin releases o2 and, binds co2 and caries it to lungs. Have nuclei and other organelles, but no hb. Wbc functions: defend against pathogens and attack abnormal cells, remove toxins and wastes.
