BIOL2117 Lecture 5: The Nucleus
Document Summary
Encloses most of a cell"s dna (the mitochondria and chloroplasts also have their own. Transcription: mrna, trna, rrna (rrna transcribed in nucleolus) Regulating localisation of transcription factors can generate gene expression (eg. nf-kappab transcription factor) Nf-kappab transcription factor - regulates the expression of b-cells to fight off illness. When nf-kappab transcription factor is inactive, it can"t get int nucleus, when it is active, it can (see that when inactive, blue and green don"t overlap, when activated, blue and green do overlap) 4. inactivated state nf-kb is bound by the inhibitor of kb (ikb) - masks nuclear localisation signal (nls) of nf-kb various stimuli can cause ikb kinase (ikk) to phosphorylate ikb, leading to its degradation (ubiquitination). Nf-kb is a transcription factor that turns on" genes that promote cell survival and proliferation (e. g. t cells, b cells, cancerous cells) New section 1 page 1 survival and proliferation (e. g. t cells, b cells, cancerous cells)
