BIOL2117 Lecture 9: Ubiquitination
Document Summary
2. mediates cyclin ubiquitination and subsequent degradation mediates degradation of cohesin complexes that link sister chromatids. Separase is inactive on metaphase because it is bound to securing. Securin degraded separase becomes active and cleaves cohesin rings; connections between sister chromatids breakdown. Antigen presentation - major histocompatibility complex class 1 (mhc class 1) - immune system. Instead of being polyubiquitination, can be monoubiquitination so it can be used as a signalling pathway. Post-translation protein modifications regulated mush of cellular biology. Addition of sugars, isoprene units, lipids, functional groups, etc. Interconnected serious of membrane compartments like the er, golgi and. Interconnected serious of membrane compartments like the er, golgi and nuclear envelope. These are from membranes that bud from the golgi, eventually forming lysosomes. Plant vacuole has the same function as the mammalian lysosomes, but are obviously structurally different. Protein degradation (with proteases) and amino acid transporters. Regulating osmolarity and turgor pressure (esp. plant cells)
