BIOL2142 Lecture 2: Protein Secretion and Translocation, Components of the Cell Wall
Document Summary
Movement of proteins from cytoplasm to plasma membrane or periplasmic space. Include transport proteins, etc proteins, proteins involved in chemotaxis and cell wall synthesis, enzymes. Movement of proteins from cytoplasm to external environment. Major pathway for all bacteria for transporting proteins across plasma membrane. Translocates proteins from cytoplasm across or into plasma membrane. Also must cross outer membrane using types i-v systems. Tat translocation system present in all domains of life. Tat pathway translocate folded proteins with "twin" arginine residues in their signal sequence. Transports proteins form cytoplasm across both plasma membrane. Type ii pathways transport proteins across outer membrane that were first translocated across plasma membrane by sac-dependant pathway. Transports virulence factors and other proteins - so in pathogens. Transfer dna from donor to recipient bacterium during conjugation. Found in both gram-positive (only transfer dna) and gram-negative. Types ii, iii and v are unique to gram-negatives. Don"t need to remember exact machinery, just overview.
