MEDN2001 Lecture Notes - Lecture 11: Therapeutic Drug Monitoring, Therapeutic Index, Pharmacogenetics
Document Summary
Pharmacokinetics and pharmacodynamics (and a taste of pharmacogenetics) Study of substances that interact with living systems through chemical processes, esp. by binding to regulatory molecules and activating or inhibiting normal bodily processes. All the substances that interact with body systems. How long it lasts in the body - effects dosage. Efficacy - how much do we need for a response vs toxicity. Plasma concentrations used to individualise dosage to target therapeutic range for an individual patient. Narrow therapeutic window - the gap between therapeutic dose and toxicity or inefficacy is small. To interpret pharmacokinetic data we look at concentration of the drug over time. When it"s an oral drug - the rate of increase is a little but slower than iv administered drug. Metabolism and excretion occur after tmax is reached. Pk - key terms -these are very good for an exam, get table of ppt. Dissolving at the site, and gets into systemic circulation.
