BMS291 Lecture Notes - Lecture 9: Minimum Inhibitory Concentration, Opportunistic Infection, Superinfection
Document Summary
One that is result of normal flora overgrowth in a site where that bacteria is not normally found. Occurs during anti-microbial therapy given for therapy or prophyllaxis. Suppress the growth of the micro-organism (e. g. bacteriostatic drug) Intact and active immune responses remove the micro-organism. Drug design aims to deliver it to a target that does not exist on human cells e. g. penicillin targets bacterial cell wall; human cells do not have a cell wall. Dependant on drug pharmacokinetics e. g. an oral antibiotic that is not absorbed from the gut to the blood stream will only effect those bacteria residing in the gut lumen. The minimum inhibitory concentration (mic) of the drug. Drug concentration needs to remain above this for a period of time to have an effect; but remain below a concentration that can cause toxicity to the human cells. Pneumonia an infection of the lower respiratory tract. Most common: pseudomonas aeruginosa, klebsiella spp. , staphylococcus aureus.
