PHA 3112 Lecture Notes - Lecture 10: Minimum Inhibitory Concentration, Drug Resistance, Gram Staining
3 Apr 2019
School
Department
Course
Professor
Document Summary
Antimicrobial therapy: infectious disease drugs most widely used drugs. Newer drugs are needed because some organisms are impervious, evolving microbial resistance and some drug toxicity. Organisms are classified as aerobic or anaerobic and by shape, and gram stain (positive = purple, or negative = pink. Antibacterial drugs can either be bacteriocidal, directly lethal, or bacteriostatic, which slow growth but do not cause cell death. Bacteria are then eliminated via the immune system and phagocytic cells. Acquired resistance: susceptibility of organism gradually total loss of sensitivity to drug and renders currently effective drug useless. Mechanism of organism resistance can include uptake of drug to export from site of action of drug in bacterium. Host (patient) factors: defenses include adequate immune system (can be impaired in deficiency). Ab is needed at site of infection in >mic (minimum inhibitory concentration stops but doesn"t kill) or mbc (minimum bactericidal concentration, which kills). Pt should not receive what they are allergic to, do.
