BIOL10002 Lecture Notes - Cell Signaling, Cell Migration, Cellular Differentiation
Wednesday, March 21, 2018
BIOL10002: Lecture 11 - Cell to Cell Communication
(Cell Signaling)
Biological processes
-Maintain a stable internal environment
-Proliferation, Apoptosis, Cell Migration, Morphogenesis, Differentiation. muscle
contraction, Stimulate enzyme activity
Different Signals lead to differentiation & proliferation of different blood
cell types
-e.g. Bone Marrow Stem cells receive a mixture of stimulating factors (Signals) to
create precursor cells, that receive a different mixture of signals to produce different
cells (macrophage vs neutrophils)
-Differentiation: Specialization — differentiated cell is a specialized cell
Signals & Receptors
-A cell can process information from its environment (information ~ signal)
-Signal may be a molecule
-The presence of a signal does not mean the cell will respond.
•In order to respond, a cell must have a specific receptor that an detect the
signal
-Receptors are often PROTEINS
•Signaling molecule — receptor binding, causing the receptor to change shape.
•Change in shape triggers cellular response
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