MIMM 214 Lecture Notes - Lecture 17: Cytotoxic T Cell, Lymph Node, Thoracic Duct

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 214
• Professor: Claire Trottier

Document Summary

Talking about differentiation that results in effector cells and their functions. Antigen presentation - activation of b cells via th2: how b cells get activated through different signals. Different roles for different t cells: different effector function of different t cells. Some activate b cells, other help macrophages kill intracellular pathogens, some directly kill infected cells. Egress to site of infection: efferent lymphatic vessels -> thoracic duct -> blood stream, exert action in controlling the infection by leaving the lymph nodes. Th2 cytokines promote tc killing and macrophage ros killing. Humoral immunity (hmi: abs promote pathogen neutralization, opsonization, complement activation, generation of bcr and tcr diversity. Downregulation of t cell activity and immunological memory: restoration of epithelial integrity, near the end of the module. Important to remember the difference between proliferation and differentiation. Effector t cells: effector t cells are the resulting differentiated t cells from activated t cells.