BIOM20001 Lecture Notes - Lecture 10: Warburg Hypothesis, Gluconeogenesis, Anabolism
20 Jul 2018
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Recognise (but not draw) the structure of substrates and products in glycolysis and gluconeogenesis. Name the enzyme involved in each reaction of glycolysis and gluconeogenesis. Understand how many atp are consumed and produced per glucose during glycolysis. State the warburg hypothesis and explain how this has influenced chemotherapeutic treatments for cancer. Compare gluconeogenesis and glycolysis highlighting the differences in subcellular location, substrate(s), cofactors(s), products(s) and enzymes used. Catabolism= energy-containing nutrients and breaking them down into stable energy-deplete end products. Has a thiol group on the end (b-mercaptoethylamine) They join up to form a glucose circle in the middle. Instead of km, kt for transport is analogous to (transporters) (enzymes) Just know that for example glut4 kt of 5 is intermediate, glut3 kt of 1. 4 is slow, glut 2 kt of 17 is extremely fast. Compartmentalisation - know which steps are happening where a. Know if reactions are cytosolic, mitochondrial, or er. Dehydrogenase, hydratase, isomerase, kinase, mutase, phosphatase, phosphorylase, synthase, etc.
