BIOM20001 Lecture Notes - Lecture 10: Glycolysis, Amphiphile, Phosphorylase
26 Jul 2018
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Anabolism: decrease in entropy, need energy to build up larger structure (stable unstable molecules, oxidation. Increase in entropy: releases energy (unstable stable molecules, reduction. No need to remember the structure of coenzyme a. Nucleotide = base + sugar + phosphate. Atp + ((cid:884)o adp + pi (cid:523)inorganic phosphate(cid:524) g" = (cid:885)0. (cid:887) kj/mol. (thioester) x-coa + ((cid:884)o x + coa-s( (cid:523)thiol(cid:524) g" = (cid:885)(cid:885). (cid:886) kj/mol. Acetoacetyl-coa is used in the switch to (cid:498)ketone bodies(cid:499) during starvation. Nad+ and nadh (nicotinamide adenine dinucleotide: thiol ester releases a lot of energy (more favourable than atp hydrolysis). Coa functions in acyl transfer reactions where x is an acetyl, acetoacetyl or other group which is transferred to another molecule. Acetyl-coa is central to metabolism; used in krebs cycle, fatty acid synthesis/oxidation, etc. Fad is the oxidised form; fadh2 is the (fully) reduced form. Only considers glut 1- 4: no need to memorize this. In liver and kidney removal of excess glucose from blood.
