BIOM20001 Lecture Notes - Lecture 60: White Blood Cell, Neutrophil, Extracellular Fluid
A protective response intended to eliminate the cause and consequence of cell injury (e.g.
micro-organism/e.g. cause: paper cut, consequence: dead cells. Inflammation cleans it up)
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Dilute - fluid to dilute toxins
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Destroy - phagocytosis
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Neutralize - by antibodies
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Initiate resolution - eliminate cause, consequence and cease inflammation
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The components of acute and chronic inflammation:
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Inflammation
Cell types: (all leukocytes)
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All cells come from hemopoeitic progenitors.
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Lymphoid progenitor give rise to NK, T, B, dendritic cells
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The boxed blood cells are referred to as leukocytes. Mechanism of recruitment is the
60 Acute Inflammation 1
Thursday, 15 May 2014
10:31 PM
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The boxed blood cells are referred to as leukocytes. Mechanism of recruitment is the
same for all
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Polymorphonuclear (neutrophils) cells have multilobed nucleus
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B-cells change morphology - become plasma cells & produce antibodies
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T,B cells have very large nucleus with very little cytoplasm when circulating blood
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Eosinophils - pink
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Macrophage has granular cytoplasm (lysosomes) and horseshoe shaped nucleus
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Rapid onset, short duration & eliminate cause of injury (e.g. bacteria) without
mounting an immune response
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Fluid and plasma protein exudation (into intravascular space)
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Neutrophil accumulation
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A large neutrophil presence (arrows)
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Acute
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Insidious onset (don't know there's a problem until clinical symptoms develop)
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Lasting days to years - longer
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Predominantly associated with lymphocytes and macrophages
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Scarring
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Chronic
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Acute vs Chronic inflammation
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Document Summary
A protective response intended to eliminate the cause and consequence of cell injury (e. g. micro-organism/e. g. A protective response intended to eliminate the cause and consequence of cell injury (e. g. micro-organism/e. g. cause: paper cut, consequence: dead cells. Initiate resolution - eliminate cause, consequence and cease inflammation. Lymphoid progenitor give rise to nk, t, b, dendritic cells. The boxed blood cells are referred to as leukocytes. Mechanism of recruitment is the same for all. T,b cells have very large nucleus with very little cytoplasm when circulating blood. B-cells change morphology - become plasma cells & produce antibodies. Macrophage has granular cytoplasm (lysosomes) and horseshoe shaped nucleus. Rapid onset, short duration & eliminate cause of injury (e. g. bacteria) without mounting an immune response. Fluid and plasma protein exudation (into intravascular space) Insidious onset (don"t know there"s a problem until clinical symptoms develop) Foreign bodies: redness and swelling and heat may remove these. Host encounters an injurious agent (microbe or dead cell)
