BIOM30001 Lecture Notes - Lecture 12: Peroxisome Proliferator-Activated Receptor, Glut4, Phosphofructokinase 2

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30001
• Professor: All

Document Summary

L12 revision of ms: fa deposit in muscle, change muscle morphology, production of mcp-1 (chemotaxis) and tnf-a, ectopic lipid droplets within the myocytes, affect glut4 movement. Biguanides: metformin: target ampk (also activated by exercise) Increase glucose uptake by muscle (glut1/4: decrease glucose production in liver (pfk-2) Thiazolidinediones: target ppar , ppar regulates gene expression (dimerise, potentiating the action of insulin in tissues, decreases glucose synthesis in liver. Glp-1 modulators: enhances insulin secretion by pancreas. Function only possible to test in animal models. Debate on equivalency, origin, identity of cells vs embryo. Function demonstrated in vitro or in vivo via animal model. We do(cid:374)"t k(cid:374)ow the ti(cid:373)e/fu(cid:374)ctio(cid:374) relatio(cid:374)ship of ips cells to es cells (prei(cid:373)pla(cid:374)tatio(cid:374) or post- implantation?: using molecular markers, these cells do not have equivalent part in the body. They do not pause in human but in other animal. By their nature and function, is describe by what they do next, not what they do at that moment.