BIOM30001 Lecture Notes - Lecture 17: Stereolithography, Spinal Cord Injury, Bioreactor
13 Sep 2018
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Document Summary
Te strategies need to be tailored to tissue targets. Biomaterial selection and biocompatibility are application specific. Success requires technical developments closely linked to clinical realities. Aims to generate new functional tissue to repair/replace tissues missing due to disease, genetic defects or trauma. Promise of: alleviating tissue shortage do not have enough donor tissue, superior results engineered tissue might be better, customised implants eg. 3d printing, new treatments where none currently suffice eg. spinal cord injury. Hurdles for te success: technical, commercial, regulatory. Tissue components: cells, matrix (microenvironment, blood supply. Traditional te: cells + growth factors, only work in very small/thin/2d tissues (skin)/avascular (cartilage, as no blood supply, 3d human scale tissues need blood supply early. Ideally mimic native tissue ecm mimic key properties. Design criteria and processes used to select, fabricate and tailor biomaterials for te. Tissue target dependent: biocompatibility: do not cause adverse effect in particular conditions.
