BIOM30001 Lecture Notes - Lecture 7: Reverse Cholesterol Transport, Foam Cell, Bile Acid

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30001
• Professor: Terry Mulhern

Document Summary

Lecture 7 metabolism in the metabolic syndrome. Cholesterol is not god or bad , the lipoproteins attached to it are. Beta oxidation = successive chopping o carbons + reduction of nadh atp via etc. Exogenous pathway = chylomicrons carry dietary lipids to the tissues e. g. adipose, heart, muscle & lactating mammary gland remnants are taken up by the liver and degraded in lysosomes. Reverse cholesterol transport = hdl originates in the liver and small intestine, picks up c from macrophages and foam cells, hdl returns c to the liver is transferred to ldl. Enterohepatic pathway = c is a precursor for bile salts which can be reabsorbed and returned to the gall bladder. Reverse cholesterol transport by hdl returns to the liver (removing it from foam cells and plaques) that"s what makes it good (more hdl back to liver = more control over plaques)