BCH 4123 Lecture Notes - Lecture 10: Thyroid Disease, Chronic Obstructive Pulmonary Disease, Weight Loss
13 Feb 2017
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Document Summary
Lipoproteins: neutral core with tag and cholesterol, outside with amphipathic lipids, apolipoproteins give structure. Chylomicrons: largest synthesized in intestine, apob48, largest and lightest, high tag content. Vldl: synthesized in liver, mostly tag, apob100. Idl: synthesized in circulation from vldl after tag hydrolysis, apob100. Ldl: further metabolism of idl, tag content is low and cholesterol esters is high, apob100. Hdl: synthesized in liver, phospholipids and cholesterol esters, apoa. Apolipoproteins: apoa only in hdl and chylomicrons, apob100 present only in ldl, idl, vldl, lp(a) (a non-modifiable risk factor for. Cvd: relative differences of apoa to apob100 can give risk of cvd. Better markers than just hdl and ldl. Homologous to ldl receptor but also recognizes apoe. Exogenous pathway: lipids are metabolized in small intestine and made into chylomicrons, chylomicrons metabolized by lpl and fatty acids are sent to. Endogenous pathway: liver produces vldl, deliver lipids to peripheral tissues, vldl metabolized to idl and ldl.
