BIOM30002 Lecture Notes - Lecture 33: Cerebral Amyloid Angiopathy, Amyloid, Neurofibrillary Tangle
Document Summary
Amyloid beta peptide aggregation and its role in alzheimer"s disease pathogenesis. Tau microtubule protein and its role in alzheimer"s disease pathogenesis. Contributing factors to disease pathogenesis - oxidative stress, biometals, neuroinflammation. Approaches to understanding the molecular and cellular biology of alzheimer"s disease. 1906 - german neuropathologist aloi alzheimer studied a patient called auguste d: wrote up the first documented case of the disease that was to be named after him. Examination of auguste d"s brain after death by alzheimer revealed globs of sticky protein (amyloid) between neurons and tangled bundles of fibrils in neurons (neurofibrillary tangles) 1910-1940 - belief that "senile dementia" is a normal part of the aging process. 1960s - ad believed to be a distinct disease (age-related dementia), not just aging. 1984 - amyloid beta peptide purified and sequenced from ad plaques (colin masters, 1994 - oxidative stress is an important feature of ad. 1994 - role of metals in amyloid plaque formation.
