HIST10014 Lecture Notes - Lecture 9: Alpha Motor Neuron, Substantia Nigra, Basal Ganglia
6 Aug 2018
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Disorders - lost motor function: patient eh (68) Awoke with sudden paralysis on his left side only. Mri revealed damage to primary motor cortex and the premotor cortex of the right hemisphere (suggests one hemisphere controls opposite side) Left arm and hand no longer used spontaneously but able to be used when: patient vr (64) instructed to do so with normal power, huntington"s disease. Mri revealed damage to right parietal (initiate use of particular arm) cortex. Atrophy of caudate nucleus indicated by gross enlargement of lateral ventricles. Manifests with motor changes - clumsiness, loss of balance, uncontrolled. Enlargement of left and right ventricle because brain tissue is dying o and part of movements etc brain is shirking so ventricles take up more space: parkinson"s disease. Disfunction in the putamen and globus pallidus, because of loss of dopaminergic (involving dopamine as a neurotransmitter) neurons in substantia nigra. Gradually lose neutrons and therefore gradually lose dopamine.
