MIIM20001 Lecture 8: Lecture 8

• School: University of Melbourne
• Department: Microbiology and Immunology
• Course: MIIM20001
• Professor: A/Prof Jason Mackenzie

Document Summary

Learning objectives: t cell activation & (cid:498)peripheral tolerance(cid:499, t cell effector functions, t cell help for b cells (isotype switching, tailoring the immune response to infection. Abbreviations to be familiar with: mhc, hla. Ag specific receptors expressed by b and t cells: discriminates between (cid:498)self and non self(cid:499) Most self reactive cells are deleted during development. (delete self reactive t cells in the periphery) Self tolerance: thymus - t cells, bone marrow - b cells, but not all antigens are expressed in the bm or the thymus. Activation of na ve t cells requires professional antigen presenting cells: cd28 on the t cell to be recognised post regulation. Dendritic cell & activation of t cell: dendritic cells largely in the periphery, peripheral tolerance when dendritic cells haven"t been activated. & costimulation hasn"t occurred: no costimulation cell death, dendritic cell activation express costimulation molecules proper activation of t cells = proliferation & clonal expansion.