MIIM20001 Lecture Notes - Lecture 35: Dengue Virus, Innate Immune System, Japanese Encephalitis

• School: University of Melbourne
• Department: Microbiology and Immunology
• Course: MIIM20001
• Professor: A/Prof Jason Mackenzie

Document Summary

Lecture 35- flipped classroom (cid:498)why can"t we generate effective vaccines to some viruses? (cid:499) Dengue virus: belongs to flavivirus genus of the flaviviridae family, other flaviviruses: yellow fever, japanese encephalitis & Antibody dependent enhancement (ade: antibodies from the first infection are cross- reactive with other denv serotypes, antibodies are sub-neutralising, fc(gamma)r recognizes antibodies. & internalizes immunocomplex: evidence suggests- this results in an increase in the number of infected cells & increased evasion of the host innate immune response- more severe infection, antibodies can enhance the infection. The leading dengue virus vaccine candidate is a formulation of chimeric viruses proteins. Overview of efficacy results against vsd: dengue virus envelope proteins- inserted into the backbone of a well known vaccine yellow fever vaccine delivering dengue envelope. Vaccine should work better hasn"t met expectations months apart for populations in endemic areas in the first 25 months. Disappointing trials of hiv vaccines: first vaccine made against subunits.