MICI 4218 Lecture Notes - Lecture 28: Viral Hemorrhagic Fever, Yellow Fever, Dengue Virus
12 May 2021
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Mici 4218 lecture 28 march 24, 2021 viral hemorrhagic fevers. What are viral hemorrhagic fevers (vhfs): vhfs can cause severe, life-threatening disease. Several countries, including the usa and russia, have conducted research on weaponizing vhf viruses: aerosolized vhf preparations are concerning because: Low infectious dose: potential for high morbidity and mortality, potential for person-to-person transmission, effective therapy and vaccines are not available. Two vhf virus families of concern: filoviruses and arenaviruses. Vhf is used to describe a severe multi-organ syndrome. This diagram illustrates all the clinical presentations that are possible with vhf. Note that these presentations do not occur all the time. Fever and other non-specific symptoms: headache, malaise, myalgias, arthralgias, nausea, diarrhea. Shock: life-threatening because body is not getting enough blood flow hypovolemic shock: hemorrhage: the bleeding is rarely life-threatening, despite the name, most are not hemorrhagic, many cause self-limiting petechial rashes.
