MIIM20002 Lecture Notes - Lecture 11: Attenuated Vaccine, Rotavirus Vaccine, Immunoglobulin Class Switching
21 Jul 2018
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Document Summary
Neutralise toxins (eg tetanus toxoid, diphtheria toxoid) to reduce damage and disease not infection. The site of infection and disease will determine where the immune response must be generated, ie infection confined to a localised site, (eg. be generated, ie infection confined to a localised site, (eg. respiratory diseases, gastroenteritis) or. Infection associated with spread from site of infection to other organs (eg. tetanus, diphtheria, rubella, hepatitis b) - protective response may have multiple sites. What kind of immune response is required? (ab isotype, cd8t cells or cd4 t cells) Live attenuated organisms: ie living organisms modified to lose pathogenicity but not immunogenicity. Empirically attenuated (eg tb, mmr [measles, mumps, rubella] vaccine) Rationally attenuated: need to understand exactly what mutations have been made in the attenuated pathogen and how likely it can revert to virulence (eg rotavirus vaccine) Subunits of the purified pathogen (eg influenza vaccines, acellular pertussis)
