MIIM20002 Lecture Notes - Lecture 28: Phylogenetics, Genomics, Cephalosporin
4 Aug 2018
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Pulse field gel electrophoresis can"t tell you gene sequence. Also it only identifies variation in a small fraction of the genome. In genomics we sequence all dna in genome. Using an algorithm we can reconstruct the ancestors using information from the population. Allows us to determine when and how populations of bacteria evolve. Process of inferring phylogeny from a set of taxa. Estimates the evolutionary relationships among a set of taxa. Evolution of new traits: is drug resistance developing in one particular clone type or in different ones. Often difficult to treat due to antibiotic resistance. First vre isolated in uk and europe, 1986. First australian vre isolate at austin health, 1994. Vse become vre when: enterococcus acquire a transposon (mobile dna element) that has the vancomycin resistance locus. In australia this resistance gene is usually the vanb locus vanb gene encodes an enzyme (ligase) that modifies the bacterial peptidoglycan cell wall so vancomycin cannot bind.
