BIOL 261 Chapter Notes - Chapter 18: Mate Choice, Coefficient Of Relationship, Inbreeding Depression
27 Feb 2017
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Population genetics = analyzes the amount of distribution of genetic variation in populations + forces that control this variation. In population genetics locus = location in genome, it can be single or stretch of many nucleotides. Simplest form of variation is a difference in nucleotide present a single nucleotide site. Microsatellite loci short sequences, 2 - 6 base pairs long repeated multiple times with different alleles having different numbers of repeats. Most prevalent type of polymorphisms usually have just 2 alleles. Usually considered common snps in a population of less common allele occurs at a frequency of about 5 % or greater. Humans common snp about every 300 to 1000 bp in genome. Snps occur within genes exons, introns + regulatory regions. Without protein-coding regions can be classified into 1 of 3 groups. Synonymous different allele encodes the same amino acid. Nonsynonymous two alleles encode different amino acids.
