NEUR30002 Lecture Notes - Lecture 10: Endoplasmic Reticulum, Angiotensin, Signal Transduction

• School: University of Melbourne
• Department: Neuroscience
• Course: NEUR30002
• Professor: Angelina Fong

Document Summary

Ionotrophic neurotransmission leads to an essp (na+ inflow) or ipsp (cl- inflow) Metabotropic transmission causes neither of these as the (cid:396)e(cid:272)epto(cid:396) does(cid:374)"t ha(cid:448)e a(cid:374)y io(cid:374) channel yet usually results in a change in ion conductance and membrane potential (neuronal excitability). * ionotrophic receptors when the neurotransmitter binds to its receptor, it directly causes an ion flow and this causes a change in membrane voltage. * metabotropic receptors do(cid:374)"t ha(cid:448)e a(cid:374) i(cid:374)(cid:271)uilt io(cid:374) (cid:272)ha(cid:374)(cid:374)el, they (cid:449)o(cid:396)k (cid:271)y i(cid:374)itiati(cid:374)g a(cid:374) i(cid:374)di(cid:396)e(cid:272)t pathway that ultimately does something to the neuron in particular. * the metabotropic transmission is not confined to the nervous system and can be found in other cells. * ionotrophic transmission is designed for rapid transmission. * in many synapses there can be both ionotropic and metabotropic receptors. * there are a great number of g protein coupled receptors - there are greater than 1000 (around 1500) different g protein coupled receptors.