NEUR30002 Lecture Notes - Lecture 11: Extracellular Fluid, Spatial Memory, Neuroglia
11 Aug 2018
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* metabotropic receptors alter ion channel conductance altering the excitability or sensitivity of the post synaptic neuron. This is done in a timeframe that will affect the neuron for hundreds of milliseconds or possibly several seconds or longer, whereas ionotropic signals start and finish within the span of 5 milliseconds. * we talk about neuromodulatory systems usually by reference to the name of the particular neurotransmitter because clusters of neurons that make a particular neurotransmitter tend to be involved in certain functions. * they often have profound effects on function and behaviour. * these systems can be based on small-molecule neurotransmitters, but can also be based on peptide neurotransmitters. * usually g protein coupled receptors their role in not signal transmission as much as altering the excitability of groups of neurons, particularly in the cerebral cortex. * dopamine midbrain movement especially its initiation, reward & pleasure. * acetyl choline pons sleep & wakefulness. * acetylcholine forebrain learning, memory, attention.
