PHYS30005 Lecture Notes - Lecture 11: Myokine, Natriuretic Peptide, Fatty Acid Metabolism

• School: University of Melbourne
• Department: Physiology
• Course: PHYS30005
• Professor: Professor

Document Summary

Lecture 11 metabolic cross-talk" between liver and muscle, exercise and disease. Direct organ to target tissue (receptor mediated event) Feedback (eg. insulin secreted to promote glucose uptake) or feedforward (eg. Feedback (eg. insulin secreted to promote glucose uptake) or feedforward (eg. adrenaline secreted under stressful situations -> detected by liver to promote glucose production for exercise) regulation. Glucose metabolism insulin, glucagon, adrenaline, cortisol. Fatty acid metabolism adrenaline, insulin, glucagon, atrial natriuretic peptide, cortisol, growth hormone (anterior pituitary gland) Others: estrogen, testosterone, t3, ras, anp, alpha-msh, ghrelin, etc. Leptin secreted from adipose tissue (impacts energy balance) Skeletal muscle, liver, adipose tissue and other tissues secrete proteins in times of increase energy demand (ie. exercise) or energy excess (ie. obesity) to influence metabolic processes. Example: muscle contraction muscle secretes thousands of myokines to influence processes such as fa oxidation, glucose uptake adipokines secreted from adipose tissue (often have detrimental effects on processes) Adipose tissue is an endocrine organ the adipokines".