IMM2011 Lecture Notes - Lecture 13: Signal Transduction, Cell Adhesion, Cell Adhesion Molecule
13 Jul 2018
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This figure shows receptors and ligand needed for t cell activation. The t cell also contains transmembrane signalling protein cd3 protein -chains and zeda chain. Normally most tcr bind to peptide-mhc with low affinity however to induce a response and subsequent t cell activation the bind of t cell to apc for longer period is through adhesion molecules (integrin) . Lfa 1: major t cell antigen that binds to its intra cellular adhesion ligand (icam-1) on apc . These interactions here are important for inhibiting the immune response we will only discuss ctla-4 briefly. The t cell also contains transmembrane signalling protein cd3 protein chains and zeda chain. This is known as the tcr complex. The long cytoplasmic domains of the cd3 and the zeda chains contain immunoreceptor tyrosine based activation motif (itam), which contains tyrosines which allows for signal transduction.
