IMM250H1 Study Guide - Final Guide: T Helper Cell, Dendritic Cell, B Cell

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Published on 6 Apr 2018
School
UTSG
Department
Immunology
Course
IMM250H1
Professor
T cells and B cells
CD4 and CD8 coreceptors
They bind to MHC outside the peptide binding area.
CD4 is for MHC 2
CD8 is for MHC 1
It increases the signal of activation when the signal is also sent through
binding of CD and MHC.
CD3 is the signalling unit
Most signal through their tail
T and B cell have a very small tail so there is need for CD3, which is an
adaptor.
Stages:
Antigen recognition
Activation
Clonal expansion
Differentiation
Effector Functions.
IL2 is the growth factor that is important in the amplification process.
Happens in the lymph nodes.
Naïve Lymphocytes need to be activated by the antigen presenting cells.
Dendritic cells are an APC and they bring antigens to the lymph nodes.
Interaction between a naïve t cell and APC is called signal 1.
Not enough because naïve have a safeguard system.
Signal 2 is done by B7 to activate them.
T cell also helps in activation of B cell
A t cell has been activated
B cell will act as APC and the T cell will be activated and express CD40
and interact with B cell to activate the B cell
Cytokines are important for IgE production
Signal 1 is TCR and
Signal 2
Signal 3 is activated by cytokines and by dendritic cells for naïve T cells.
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