PHY3181 Lecture Notes - Lecture 3: Leydig Cell, Sertoli Cell, Anterior Pituitary
10 Feb 2019
School
Department
Course
Professor
Document Summary
Collection of glands that synthesise + secrete hormones into bloodstream where they act on. Have no ductal system - ductless glands. As opposed to exocrine glands: secrete their products using ducts. Lh/fsh: leydig + sertoli cells convert testosterone estrogen, have aromatase enzyme, sertoli cell major hormone produced = inhibin. Inhibin only has negative feedback mechanisms at anterior pituitary not at hypothalamus. Because it only regulates fsh (if it fed to hypothalamus would regulate both: leydig cell major hormone produced = testosterone. Gnrh is not a steroid is a peptide. Short chains of linked amino acids: proteins/glycoproteins. Long chains of linked amino acids: steroids. Derived from cholesterol: amino acid derivatives norepinephrine. Rely on enzymes like aromatase and 5- reductase. Feedback effects on the secretion and actions of gnrh. Important roles in a range of reproductive functions in both sexes. No evidence of testosterone feedback at the pituitary. Only at the hypothalamus a species specific difference.
