PSY2071 Lecture Notes - Lecture 12: Synaptic Pruning, Impulsivity, Prefrontal Cortex
5 Jun 2018
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Psy2071 – Week 12 – Addiction
• what is addiction?
•
o neuroplasticity changes correlate with compulsivity - loss of
control
• natural reinforces create habituation - drugs do the opposite -
sensitisation -
• drugs - create deficits in the way the prefrontal cortex works
• vulnerability pathways into addiction
•
o genes
o
▪ effect brain circuits - implications for personality traits
▪ relationship between genetic vulnerability and actual
problem
▪ different genetic systems associated with drug addiction
vulnerability
▪ mesolimbic dopamine system
▪
▪ full of D2 receptors - become energised with
potentially rewarding activities
▪ reward processing
▪ serotonin
▪
▪ 5-HTT
▪ determines personality traits etc - negative effective
system
▪ related to negative effectivity
▪ dopamine D4 receptors, DAT
▪
▪ quartical dopamine system
▪ related to executive functions and control
o brain circuits
o
▪ central dopamine system
▪ negative effective system
▪
▪ amygdala
▪
o personality traits
o
▪ positive emotionality - extraversion - related to reward
seeking
▪ negative system
▪
▪ darker
▪ greater risk
▪ control
▪
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