MEDI7212 Lecture 70: W10 - Cardiomyopathy
Document Summary
Secondary cardiomyopathy - myocardial involvement as a component of a systemic or multiorgan disorder: this will discuss the cardiomyopathies related to anatomic abnormalities of the heart falling into 3 pathological patterns. Dilated cardiomyopathy: definition, morphologically and functionally characterised by progressive cardiac dilation and contractile (systolic) dysfunction, usually with concomitant hypertrophy, pathogenesis. Dcm cases whereby titin connects z and m bands to limit passive range of motion of sarcomere during stretching: gene deletion causing defect in oxidative phosphorylation, gene mutation encoding enzymes for b-oxidation of fatty acids. Myocarditis: myocarditis may progress to dcm via certain viruses (eg coxsackie. Iron overload: hereditary hemochromatosis or multiple transfusions. Interference with metal-dependent enzyme systems or injury from iron-mediated production of ros. A - four chamber dilation and hypertrophy; mural thrombus (arrow) B - myocyte hypertrophy and interstitial fibrosis (collagen in blue); histologic abnormalities are nonspecific and don"t point to a specific etiology: clinical features, most common age group is 20-50yo.
