HUBS1404 Lecture Notes - Lecture 18: Pancreatic Islets, Common Bile Duct, Pancreatic Juice
19 Jul 2018
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Document Summary
If this gets blocked peptidases get backed up into the pancreas - if they activate will begin to digest. Activation of proenzymes - regulation of pancreatic secretion: activation cascade for trypsinogen. Same mechanisms controlling digestion in general ie neural/hormonal. Secretin - released by intestinal mucosa exposed to gastric hcl and fatty chyme: ^ hco3. Rich secretion from duct cells: cck - released with protein fat/chyme, ^ acini secretion of enzyme0 rich fluid and potentiates secretin, vagal ^ pancreatic secretions during cephalic and gastric phases. In the duodenum - enter in inactive form: entry of enteropeptidase cleaves part off, tripsinogen --> tripsen, chymotrysinogen --> chymotrypsin, procarboxypeptidase --> carboxypeptidase, enteropeptidase = brush boarder enzyme. Some mechanisms controlling digestion in general ie neural/hormonal. Secretin - released by intestinal mucosa exposed to (stimulated by) gastric hcl and fatty chyme increases hco3. Islets are richly innervated by both parasymp and symp. Cephalic phase of digestion causes increase in insulin secretion, mediated by vagus.
