BIOL214 Lecture Notes - Lecture 8: Pyruvate Dehydrogenase Complex, Hexokinase, Oxidative Phosphorylation
Document Summary
Know the major control points of glycolysis: hexokinase (1, phosphofructokinase-1 (3, pyruvate kinase (10) Know the hormonal and allosteric regulators of these enzymes. Know key isoenzymes and tissue specific differences between them. Know regulatory mechanisms for the pyruvate dehydrogenase complex. Know important control points of the tca cycle and oxidative phosphorylation. Major allosteric control points in glycolysis: 1 = glucose g-6-p, 3 = f6p f-1,6-bp, 10 = phosphoenol pyruvate pyruvate. Insulin responds to high blood glucose (secreted by pancreas b cells: glucagon responds to low blood glucose (secreted by pancreas a cells) Glucagon raises blood glucose: produced by alpha cells of pancreas. In liver, reduces [fructose-2,6-biphosphate] so inhibits glycolysis, stimulates gluconeogenesis. Inhibits pyruvate kinase: prevents phosphoenolpyruvate from being converted to acetyl-coa. First control point of glycolysis is at reaction #1 catalysed by hexokinase: glucose glucose-6-phosphate, g-6-p is an important branch point in metabolism has multiple fates, hexokinase.
