BIOL1008 Lecture Notes - Lecture 7: Ileocecal Valve, Enteric Nervous System, Small Intestine

40 views15 pages
Lecture 7: Microbiome and other connections
Nutrition- related chronic diseases
Activities of the digestive system
- Ingestion of food into mouth
- Mechanical and chemical digestion of food to produce chyme and release soluble
nutrients
- Movement of chyme along the digestive tract
- Absorption and translocation to blood of small molecular weight nutrients.
- Elimination of indigestible substances and waste products via defecation
- Monitoring and Regulation of GIT state in relation to systemic demands
Gut functions beyond digestion and absorption
- Large scale: Digestive tract/alimentary canal
Stomach - acidity kills microbes
Intestinal Epithelium barrier to microbes
- Cellular scale: Functionally distinct epithelial cells
Enterocytes nutrient and taste receptors
Enteroendocrine cells release hormones
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 15 pages and 3 million more documents.

Already have an account? Log in
2
M cells engulf particles from gut e.g. insoluble food
Gut accessory organs have functions beyond digestion and absorption
- Accessory organs
Liver also metabolic processing of absorbed compounds (nutrients and toxins)
Pancreas also endocrine functions
Microbiome extensive metabolic transformations of food
Enteric nervous system (ENS) bi-directional connection of brain and gut
Gut-associated lymphoid tissue (GALT) mucosal and systemic immune functions
Microbiome- stable microbial community of a defined habitat (biome)
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 15 pages and 3 million more documents.

Already have an account? Log in
3
- The stomach has few microbes, most of which are transiently present.
- Small intestine is physico-chemically distinct from the large intestine (ileocecal valve).
- The small intestine and large intestine have different microbial community structure.
The most obvious difference is cell density.
Evidence from comparing the presence/absence of microbes
The presence of microbes changes our food requirements.
- Quantity - Less food is eaten by animals that are colonized.
- Quality - The diet fed to germ-free animals requires vitamin supplementation and a
simple carbohydrate profile.
Macronutrients are things we need in large amounts. Used for energy and as precursors for
synthesis.
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 15 pages and 3 million more documents.

Already have an account? Log in

Document Summary

Mechanical and chemical digestion of food to produce chyme and release soluble nutrients. Movement of chyme along the digestive tract. Absorption and translocation to blood of small molecular weight nutrients. Elimination of indigestible substances and waste products via defecation. Monitoring and regulation of git state in relation to systemic demands. M cells engulf particles from gut e. g. insoluble food. Gut accessory organs have functions beyond digestion and absorption. Liver also metabolic processing of absorbed compounds (nutrients and toxins) Enteric nervous system (ens) bi-directional connection of brain and gut. Gut-associated lymphoid tissue (galt) mucosal and systemic immune functions. Microbiome- stable microbial community of a defined habitat (biome) The stomach has few microbes, most of which are transiently present. Small intestine is physico-chemically distinct from the large intestine (ileocecal valve). The small intestine and large intestine have different microbial community structure. The presence of microbes changes our food requirements. Quantity - less food is eaten by animals that are colonized.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions