BIOL1008 Lecture Notes - Lecture 22: Autoimmune Disease, Bone Marrow, Leukemia

• School: University of Sydney
• Department: Biology
• Course: BIOL1008
• Professor: Philip Poronnik

Document Summary

Immunological tolerance is a system for determining which lymphocyte clones will be allowed to survive. Central (occurs in the primary lymphoid tissues) A breakdown in tolerance can lead to autoimmune disease. Many autoimmune diseases are linked to the genes responsible for: t cell activation, maintaining immunological tolerance. Autoimmune disease is often preceded by an infection. Other environmental and host factors may contribute: Many autoimmune diseases are more common in women: how sex affects immunological tolerance is not known. In other contexts (e. g. multiple sclerosis), a lack of uv rays from sunlight is a contributing factor to autoimmunity. Autoimmune disease may be organ specific or systemic. Autoimmune diseases involve all aspects of the adaptive immune response. The insulin-secreting b cells in the pancreas are targeted of t cells. Activated cytotoxic t cells find their way to the pancreas. B cell-specific ctls kill the b cells. The a a(cid:374)d cells are unaffected: highlights exquisite antigen specificity.