BIOL1008 Lecture 19: Lecture 19
9 Jun 2018
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Lecture 19: The Yin and Yang of Human Defense
Gastrointestinal tracts evolved to accommodate microbes- we want them there
Microbiome refers to the stable microbial community of a defined habitat (biome)
Small intestine is physico-chemically distinct from the large intestine (ileocecal valve) and a site
of competition with microbes.
The Large intestine has distinct conditions, far higher microbe cell density and is a site of co-
operation with microbes.
Most other internal organs are sites where presence of microbes not tolerated.
Nutrition-related chronic diseases connect diet, gut microbiome and immune functions
2
LO Immune balance: need a broad view of immune functions that encompass more than just
defence
Microbe growth in our gut is controlled. Cells of our immune system are not the major source
of control
Diet changes our relationship with our microbiome → has consequence for immune balance
How does nutrient intake (diet) contribute to microbe control and immune balance?
3
Microbe growth in our gut lumen is controlled not prevented- primary control is
environmental regulation
Cell density: the number of microbes in an open system is determined by balance of cell
production and cell loss
Document Summary
Lecture 19: the yin and yang of human defense. Gastrointestinal tracts evolved to accommodate microbes- we want them there. Microbiome refers to the stable microbial community of a defined habitat (biome) Small intestine is physico-chemically distinct from the large intestine (ileocecal valve) and a site of competition with microbes. The large intestine has distinct conditions, far higher microbe cell density and is a site of co- operation with microbes. Most other internal organs are sites where presence of microbes not tolerated. Nutrition-related chronic diseases connect diet, gut microbiome and immune functions. Lo immune balance: need a broad view of immune functions that encompass more than just defence. Cells of our immune system are not the major source of control. Diet changes our relationship with our microbiome has consequence for immune balance. Microbe growth in our gut lumen is controlled not prevented- primary control is environmental regulation.
