PHAR3817 Lecture Notes - Lecture 5: Passive Smoking, Chronic Obstructive Pulmonary Disease, Active Management
22 Jul 2018
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Document Summary
Based on the global initiative for chronic obstructive lung disease (gold) Copd is a preventable and treatable disease, is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the severity in individual patients". Copd and airflow limitation: mixture of small airway disease and parenchymal destruction, relative contribution differs with individuals. Structural changes, narrowing of small airways, destruction of lung parenchyma, loss of alveolar attachment and decreased lung elastic recoil: diminish the ability of airways to remain open during expiration. There is some to a lot of damage to connective tissue. Chronic inflammation cause damages to tissue over time (connective) Alveoli detached from connective tissue (no transfer of oxygen and carbon dioxide) Lowering lung elasticity result the diminished ability of airways to remain open (using extra muscles to push air out)
