PHAR3817 Lecture Notes - Lecture 9: Xanthine Oxidase, Fluticasone, Budesonide

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Asthma prevalence in australia: for 2007-08 the prevalence of current asthma in australia was estimated about 1 in 10, equivalent to about 2 million people. Asthma is a chronic lung disease-> can be controlled but not cured. We now know that airway remodelling (permanent damage) is caused by asthma and therefore it is very important to manage asthma properly by using preventers etc. to minimize damage. Histamine is released responding to an allergen, causes bronchoconstriction. Wbc bring ketokines and inflammatory mediators and rush to cell. The airway smooth muscle becomes bulkier all the time as you work harder to breathe making airway narrower. Labas not mentioned here although they can be classed here. Eformeterol and salmeterol are laba"s-> laba"s are only used in combination with ics for asthma treatment, never alone. One or two of: daytime symptoms >2 days. Any symptoms during night or on waking week. Short dose oral steroids: high dose ics/ laba with.

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